Familial Malignant Melanoma

Familial Malignant Melanoma - Overview

Approximately 3-15% of all malignant melanomas (MM) are familial cases. MM is a highly heterogeneous tumour type from a genetic perspective. Pedigrees with disease confined to a single generation of siblings or MM occurring among second- or third-degree relatives suggest multifactorial polygenic inheritance. However, not infrequently, within large families aggregations of MM are consistent with...

Primary duodenal malignant melanoma: A case report

Background: Melanoma is a neoplasm derived commonly from melanocytic cells of skin. Although coetaneous presentation of malignant melanoma is easily recognizable, the presentation of melanoma in other organs is so confusing. In particular, when it metastasizes to other organs, many bizarre figures and unusual organs may be involved. In this report, we present a case of primary duodenal malignan...

Malignant Mucosal Melanoma of the Maxillary Sinus

Sinus mucosal malignant melanoma, is a rare type of melanoma with poor prognosis which is usually occurred in the adults. This is a rare case of a 33-year-old man presenting 2-week-long headache and nasal obstruction with the emphasis on the importance of Immunohistochemical staining to help the diagnosis.

Familial melanoma

Familial melanoma.

Approximately 5% to 10% of cases of cutaneous melanoma occur in families that have a hereditary predisposition for this disease. In 20% to 40% of such melanoma families, germline mutations in the CDKN2A gene have been identified. Apart from a high risk of melanoma, a proportion of kindreds that have familial melanoma also have an increased risk of pancreatic carcinoma. Guidelines for management...